Group members

Carlos Crespo Rupérez
University of Valencia. Valencia.

Principal Investigator:
Carlos Crespo Rupérez
José Miguel Blasco Ibáñez
Juan Nácher Roselló
Emilio Varea López

Members of the equipment:
Francisco Javier Gracia Llanes
María Gutiérrez Mecinas
Teresa Liberia Vayá
Paula Martínez Valero

Publications 2006-2008

Domínguez, M.I., Blasco-Ibáñez, J.M., Crespo, C., Nacher, J., Marqués-Marí, A.I., Martínez-Guijarro., F.J. Neural over-excitation and implication of NMDA and AMPAreceptors in a mouse model of temporal lobe epilepsy implying zinc chelation. Revista: 905832 - Epilepsia. Volumen: 47 Número: --- Páginas, inicial: 887 final: 899 Año: 2006.

Gutièrrez-Mecinas M, Crespo C, Blasco-Ibáñez JM, Nácher J, Varea E, Martínez-Guijarro FJ. Migrating neuroblasts of the rostral migratory stream are putative targets for the action of nitric oxide. Revista: 902599 - European Journal of Neuroscience. Volumen: 26 Número: --- Páginas, inicial: 392 final: 402 Año: 2007.

Marqués-Mari AI, Nacher J, Crespo C, Gutierrez-Mecinas M, Martinez-Guijarro FJ, Blasco-Ibanez JM. Loss of input from the mossy cells blocks maturation of newly generated granule cells. Revista: 908742 - Hippocampu. Volumen: 17 Número: 7 Páginas, inicial: 510 final: 524 Año: 2007.

Gutièrrez-Mecinas M, Blasco-Ibáñez JM, Nacher J, Varea, E., Martínez-Guijarro FJ, Crespo C.
Título: Distribution of the A3 subunit of the cyclic nucleotide-gated ion channels in the main olfactory bulb of the rat. Revista: 902663 - Neuroscience.
Volumen: 153 Número: --- Páginas, inicial: 1164 final: 1176 Año: 2008.

Lines of work

Work in our laboratory is centred on the detailed study of the connectivity maps in the mammalian olfactory bulb. Our current research lines are:
1. To study the synaptic connectivity of different interneuron populations in the olfactory bulb.
2. To study the subcortical modulation of circuits in the olfactory bulb.
3. To analyse the local circuits in the olfactory bulb that use nitric oxide.
We use the rat (Rattus norvegicus) and occasionally the common hedgehog (Erinaceus europaeus) olfactory bulb as our model species.

Experimental techniques

In our laboratory, the top priority is a multidisciplinary approach to the study of the anatomo-functional relationships in the nervous system. Therefore, we try to incorporate all types of techniques:

1. Histological processing for optical microscopy.
2. Histological processing for transmission electron microscopy.
3. Immunocytochemical labelling.
4. Combination of immunocytochemical labelling and electron microscopy:
• Pre-embedding immunocytochemical labelling with DAB and colloidal gold.
• Post-embedding immunocytochemical labelling with colloidal gold
• Double-labelling pre-embedding with DAB and colloidal gold.
• Double labelling pre-embedding with DAB and post-embedding with colloidal gold.
5. Connection tracing techniques.