Group members
Alberto Ferrús Gamero
CSIC. Cajal Institute. Madrid.
Principal Investigator:
Alberto Ferrús Gamero
Members of the equipment:
Angel Acebes Vindel
Sheila Jordan Alvarez
Alicia Mansilla
Jaime Jurado
Valerie Chevalier |
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Publications 2006-2008
Grau B, Popescu C, Torroja L, Ortuño-Sahagún D, Boros I, Ferrús A. Transcriptional adaptor ADA3 of Drosophila melanogaster is required for histone modification, position effect variegation, and transcription. Mol Cell Biol. 2008, 28:376-385.
Romero-Pozuelo J, Dason JS, Atwood HL, Ferrús A. Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology. Eur J Neurosci. 2007 26:2428-2443.
Martín-Peña A, Acebes A, Rodríguez JR, Sorribes A, de Polavieja GG, Fernández-Fúnez P, Ferrús A. Age-independent synaptogenesis by phosphoinositide 3 kinase. J Neurosci. 2006, 26:10199-10208.
Winther AM, Acebes A, Ferrús A. Tachykinin-related peptides modulate odor perception and locomotor activity in Drosophila. Mol Cell Neurosci. 2006, 31:399-406. |
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Lines of work
• Formation of synapses. Identification of cell signalling pathways that control the number of synapses a neuron establishes with its target. At present, a new pathway mediated by PI3K and AKT has been identified.
• Modulation of the number of synapses. To study the mechanisms by which the number of synapses changes, under physiological or pathological conditions, during sensory perception or during the regulation of substrate proteins by ubiquitination.
•Regulation of Troponin I expression. To further our knowledge of the mechanisms used by this gene to generate such a wide repertoire (10) of isoforms and the functional role of these during sarcomere formation.
Experimental techniques
• Model species: Drosophila melanogaster
• Behaviour: Analysis of olfactory behaviour (T-maze in adults) and locomotor behaviour (Buridán’s paradigm).
• Use of genetic tools and constructions.
• Molecular and cell biology techniques.
• Optical and Confocal microscopy.
• Electron microscopy.
• Immunohistochemical and histological techniques. |
