Group members
Alino Martínez Marcos
University of Castilla-La Mancha. Ciudad Real.
Principal Investigator:
Alino Martinez Marcos
Members of the equipment:
Isabel Ubeda Bañón
Carlos de la Rosa Prieto
Daniel Saiz Sanchez |
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Publications 2009 - 2010
Saiz-Sanchez D, Ubeda-Bañon I, de la Rosa-Prieto C, Argandoña-Palacios L, Garcia-Muñozguren S, Insausti R, Martinez-Marcos A: Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease. Exp Neurol. 2010 Jun; 223(2): 347-50. Epub 2009 Jun 25 (PubMed - in process)
Ubeda-Bañon I, Saiz-Sanchez D, de la Rosa-Prieto C, Mohedano-Moriano A, Fradejas N, Calvo S, Argandoña-Palacios L, Garcia-Muñozguren S, Martinez-Marcos A.: Staging of alpha-synuclein in the olfactory bulb in a model of Parkinson's disease: Cell types involved- Mov Disord. 2010 Jun 23. (PubMed - as supplied by publisher)
Ubeda-Bañon I, Saiz-Sanchez D, de la Rosa-Prieto C, Argandoña-Palacios L, Garcia-Muñozguren S, Martinez-Marcos A.: Alpha-Synucleinopathy in the human olfactory system in Parkinson's disease: involvement of calcium-binding protein- and substance P-positive cells. Acta Neuropathol. 2010 Jun; 119(6):723-35. Epub 2010 Apr 8(PubMed - in process)
De la Rosa-Prieto C, Ubeda-Bañón I, Mohedano-Moriano A, Pro-Sistiaga P, Saiz-Sanchez D, Insausti R, Martínez-Marcos A. Subicular and CA1 hippocampal projections to the accessory olfactory bulb.
Hippocampus, DOI 10.1002/hipo.20495 (2009).
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Research Lines
In the laboratory, we study the olfactory and vomeronasal systems from three different perspectives
• Connective organization of these systems.
• Study of the neurogenesis in the adult vomeronasal and accessory bulb epithelium.
• Neuroanatomical changes in the human and transgenic mouse olfactory system in Parkinson’s and Alzheimer’s disease.
Experimental techniques
• Analysis of the neuronal connections through iontophoretic injection of tracers under sterotaxic control.
• Immunohistochemistry and immunofluorescence, even in human brain tissue.
• Detection of neurogenesis (BrdU) and apoptosis (TUNEL, Caspase-3).
• Genotyping by quantitative PCR of transgenic mouse models of Parkinson’s and Alzheimer’s disease. |
