Group members

Laura López-Mascaraque
CSIC. Cajal Institute, Madrid.

Principal Investigator:
Laura López-Mascaraque

Members of the equipment:
Jean Gascuel
Nieves Salvador Cobos
Eduardo Martín López
Jorge García Marqués
María Figueres Oñate
Isabel Alvarez

Publications 2006-2008

Martin-López, E., Blanchart, A., De Carlos, J. A. and Laura López-Mascaraque, L. 2011. DAB1 (Disable homolog-1) reelin adaptor protein is overexpressed in the olfactory bulb at early postnatal stages. PLoS ONE, in press.

Blanchart, A., Martín-López, E., De Carlos, J.A. and López-Mascaraque, L. 2011. Peripheral contributions to Olfactory Bulb cell populations (Migrations towards the Olfactory Bulb). Glia, 59: 278-292.

García-Moreno, F., Pedraza, M., Di Giovannantonio, L.G., Di Salvio, M., López-Mascaraque, L., Simeone, A. and De Carlos, J.A. (2010) A neuronal migratory pathway crossing brain boundaries populates amygdala nuclei. Nature Neurosci., 13: 680-189.

Ceci, M.L., López-Mascaraque, L. and De Carlos, J. A. 2010. The influence of the environment on Cajal-Retzius cell migration. Cereb. Cortex, 20: 2348-2360.

García-Marqués, J., De Carlos, J., Greer, C.A. and López-Mascaraque, L. 2010. Different astroglia permissivity controls the migration of olfactory bulb interneuron precursors. Glia. 58: 218-230.

Roberts, A.C., Diez-García, J., Rodríguez, R.M, López, I.P., Lujan, R., Martínez-Turrillas, R., Pico, E., Henson, M.A, Bernardo, D.R., Jarrett, T.M., Clendeninn, D.J., López-Mascaraque, L., Feng, G., Lo, D.C., Wesseling, J.F., Wetsel, W.C., Philpot, B.D. and Perez-Otaño, I. 2009 .Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. Neuron: 63: 34.

Blanchart, A., Romaguera, M., García-Verdugo, J.M., De Carlos, J.A and López-Mascaraque, L. 2008. Synaptogenesis in the mouse olfactory bulb during glomerulus development. Europ. J. Neurosci., 27: 2838–2846.

García-Moreno, F., López-Mascaraque, L. and De Carlos, J. 2008. Early Telencephalic Migration Topographically Converging in the Olfactory Cortex. Cereb. Cortex., 18, 1239–1252.

De Castro, F., López-Mascaraque, L. and De Carlos, J. 2007. Cajal: Lessons on brain development. Brain Research Reviews, 55/2: 481-489. García-Moreno, F., López-Mascaraque, L. and De Carlos, J. 2007. Origins and migratory routes of murine Cajal-retzius cells. J. Comp. Neurol., 500: 419-432.

Blanchart , A., De Carlos, J.A and López-Mascaraque, L. 2006. Time frame of mitral cell development in mice olfactory bulb. J. Comp. Neurol ., 496:529–543.

López-Mascaraque, L. 2006. La vía olfatoria: El error de Cajal. Publicado en: Perspectivas sobre Cajal y su obra: 100 años después. Editores: Ferrus & Gamundi. Editorial Pirámide - Universidad de las Islas Baleares. Pp. 213-233.

García-Marqués, J., Blanchart, A. y López-Mascaraque, L. 2006. Construyendo un bulbo olfativo. Publicado en: La Olfacción en España. Editorial: SBI, SL. Editores: Alonso, De Castro & López-Mascaraque. Pp.55-69.

Lines of work

• Mechanisms involved in the mobility and directionality of cell migration during the development of the olfactory system.
• Epigenetic factors involved in the differentiation of different types of neurons in the olfactory bulb.
• Analysis of the regional influence of astroglia on the post-natal migration and differention of the interneurons in the OB.

- Structural and functional effects of sensory deprivation

Experimental techniques

• Histological and immunohistochemical techniques
• Classical histological methods: Golgi method
• “in vivo” and “in vitro” cell tracing using fluorescent markers, lectins, retroviruses and lentiviruses
• Cell and organotypic cultures.
• Co-cultures of explants in collagen networks
• Whole embryo cultures
• Synthesis of gene probes, in-situ hybridisation, vector construction. Gene over-expression-repression using retro- and lentiviral technology • Experimental embryology: manipulation of embryos and intrauterine injections.
• Intracranial surgery to inject markers under pressure or by iontophoresis.